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MDRD Equation:
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The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, and sex. It was developed to provide a more accurate assessment of kidney function than the Cockcroft-Gault equation, particularly in patients with chronic kidney disease.
The calculator uses the MDRD equation:
Where:
Explanation: The equation accounts for the inverse relationship between creatinine and GFR, with adjustment for age-related decline in kidney function and gender differences in muscle mass.
Details: GFR estimation is essential for diagnosing and staging chronic kidney disease, monitoring disease progression, and adjusting medication dosages for renally excreted drugs.
Tips: Enter serum creatinine in mg/dL, age in years, and select gender. All values must be valid (creatinine > 0, age between 1-120). For most accurate results, use fasting morning blood samples.
Q1: What's the difference between MDRD and CKD-EPI equations?
A: CKD-EPI is generally more accurate, especially at higher GFR levels (>60 mL/min/1.73m²), while MDRD may underestimate GFR in healthier individuals.
Q2: What are normal GFR values?
A: Normal is generally ≥90 mL/min/1.73m², though values decline with age. Below 60 for 3+ months indicates CKD.
Q3: When was the MDRD equation developed?
A: The equation was developed in 1999 based on data from the Modification of Diet in Renal Disease study.
Q4: Are there limitations to the MDRD equation?
A: Yes, it's less accurate in extremes of age/weight, amputees, pregnant women, and those with rapidly changing kidney function or unusual muscle mass.
Q5: Should I use MDRD or CKD-EPI?
A: CKD-EPI is now preferred for most clinical situations, but MDRD may still be used in some laboratories and for comparison with older studies.